Novel investigational therapeutics for panic disorder
作者： Giampaolo Perna , Koen Schruers , Alessandra Alciati , Daniela Caldirola
DOI: 10.1517/13543784.2014.996286
关键词: Angiotensin receptor 、 Cannabinoid 、 Animal studies 、 Orexin 、 Anxiety disorder 、 Glutamate receptor 、 Panic disorder 、 Translocator protein 、 Pharmacology 、 Medicine
摘要: Introduction: Panic disorder (PD) is a common disabling anxiety associated with relevant social costs. Effective anti-panic medications exist but have several drawbacks. From clinical perspective, there still strong unmet need for more effective, faster acting and tolerable therapeutic treatments.Areas covered: The authors review the available results on novel mechanism-based drugs that are under investigation in animal studies up to Phase II studies. preclinical investigated include: modulators of glutamate/orexin/cannabinoid systems, corticotrophin-releasing factor 1 (CRF1)/arginine vasopressine V1B/angiotensin receptor antagonists neuropeptide S. I/II glutamate system, isoxazoline derivative, translocator protein (18 kDa) ligands CRF1/neurokinin antagonists.Expert opinion: There has been little progress recent times. However, glutamate- orexin-related molecular ta...
narcis.nl参考文章(98)
Vincenzo Di Marzo, Targeting the endocannabinoid system: to enhance or reduce? Nature Reviews Drug Discovery. ,vol. 7, pp. 438- 455 ,(2008) , 10.1038/NRD2553
Laszlo Papp, Jack M. Gorman, Susan Browne, Jose Martinez, Lawrence A. Welkowitz, Instructional Set and Physiological Response to CO2 Inhalation American Journal of Psychiatry. ,vol. 156, pp. 745- 748 ,(1999) , 10.1176/AJP.156.5.745
I Kola, The State of Innovation in Drug Development Clinical Pharmacology & Therapeutics. ,vol. 83, pp. 227- 230 ,(2008) , 10.1038/SJ.CLPT.6100479
Giampaolo Perna, Giuseppe Guerriero, Paolo Brambilla, Daniela Caldirola, Panic and the Brainstem: Clues from Neuroimaging Studies Cns & Neurological Disorders-drug Targets. ,vol. 13, pp. 1049- 1056 ,(2014) , 10.2174/1871527313666140612112923
Peter Anderer, Bernd Saletu, Michael Wolzt, Svetlana Culic, Alessandro Assandri, Fabrizio Nannipieri, Sergio Rosini, Gerda M. Saletu-Zyhlarz, Double-blind, placebo-controlled, multiple-ascending-dose study on the effects of ABIO-08/01, a novel anxiolytic drug, on perception and cognition, utilizing event-related potential mapping and low-resolution brain electromagnetic tomography. Human Psychopharmacology-clinical and Experimental. ,vol. 23, pp. 243- 254 ,(2008) , 10.1002/HUP.920
Rafael C. Freire, Giampaolo Perna, Antonio E. Nardi, Panic Disorder Respiratory Subtype: Psychopathology, Laboratory Challenge Tests, and Response to Treatment Harvard Review of Psychiatry. ,vol. 18, pp. 220- 229 ,(2010) , 10.3109/10673229.2010.493744
Alessandro Colasanti, Gabriel Esquivel, Koen J. Schruers, Eric J. Griez, On the Psychotropic Effects of Carbon Dioxide Current Pharmaceutical Design. ,vol. 18, pp. 5627- 5637 ,(2012) , 10.2174/138161212803530745
Thatiane de Oliveira Sergio, Ailton Spiacci, Hélio Zangrossi, Effects of dorsal periaqueductal gray CRF1- and CRF2-receptor stimulation in animal models of panic. Psychoneuroendocrinology. ,vol. 49, pp. 321- 330 ,(2014) , 10.1016/J.PSYNEUEN.2014.07.026
Walter Backes, Machteld Marcelis, Paul Hofman, Eric Griez, Koen Schruers, Liesbet Goossens, Nicole Leibold, Ronald Peeters, Gabriel Esquivel, Inge Knuts, Brainstem response to hypercapnia: A symptom provocation study into the pathophysiology of panic disorder Journal of Psychopharmacology. ,vol. 28, pp. 449- 456 ,(2014) , 10.1177/0269881114527363
Marco Battaglia, Silvana Bertella, Anna Ogliari, Laura Bellodi, Enrico Smeraldi, Modulation by Muscarinic Antagonists of the Response to Carbon Dioxide Challenge in Panic Disorder Archives of General Psychiatry. ,vol. 58, pp. 114- 119 ,(2001) , 10.1001/ARCHPSYC.58.2.114