Congenital malformations after intracytoplasmic injection of spermatids.

作者: H. Zech

DOI: 10.1093/HUMREP/15.4.969

关键词: AzoospermiaSpermatidBiologyMicroinjectionInfertilityAndrologyIntracytoplasmic sperm injectionTesticular sperm extractionEmbryo transferPregnancy

摘要: Spermatid microinjection into oocytes was applied in cases of intracytoplasmic sperm injection (ICSI)/testicular extraction (TESE) where no spermatozoa could be found numerous testicular samples. Although several pregnancies were obtained with this procedure, serious concerns remain regarding its safety. the relevance spermatids is by means certain, we wish to report that from four after elongated spermatids, two major malformation resulted.

参考文章(18)
Ernst Knobil, Jimmy D. Neill, The Physiology of reproduction Psychoneuroendocrinology. ,vol. 7, pp. 641- 642 ,(1988)
R.G. Edwards, Widening perspectives of intracytoplasmic sperm injection. Nature Medicine. ,vol. 5, pp. 377- 378 ,(1999) , 10.1038/7370
A. C. Chandley, T.B. Hargreave, Genetic anomaly and ICSI. Human Reproduction. ,vol. 11, pp. 930- 932 ,(1996) , 10.1093/OXFORDJOURNALS.HUMREP.A019323
S. Fishel, S. Green, M. Bishop, S. Thornton, A. Hunter, S. Flemiry, S. Al-Hassan, Pregnancy after intracytoplasmic injection of spermatid The Lancet. ,vol. 345, pp. 1641- 1642 ,(1995) , 10.1016/S0140-6736(95)90149-3
Yasuhisa Araki, Mitsuhiro Motoyama, Atsumi Yoshida, Sang-Yong Kim, Hiro Sung, Shigeo Araki, Intracytoplasmic injection with late spermatids: A successful procedure in achieving childbirth for couples in which the male partner suffers from azoospermia due to deficient spermatogenesis Fertility and Sterility. ,vol. 67, pp. 559- 561 ,(1997) , 10.1016/S0015-0282(97)80086-6
A Ogura, R Yanagimachi, Spermatids as male gametes. Reproduction, Fertility and Development. ,vol. 7, pp. 155- 158 ,(1995) , 10.1071/RD9950155
S. Kahraman, G. Polat, M. Samli, E. Sozen, O. D. Ozgun, K. Dirican, T. Ozbicer, Multiple pregnancies obtained by testicular spermatid injection in combination with intracytoplasmic sperm injection. Human Reproduction. ,vol. 13, pp. 104- 110 ,(1998) , 10.1093/HUMREP/13.1.104
P. Vanderzwalmen, H. Zech, A. Birkenfeld, M. Yemini, G. Bertin, B. Lejeune, M. Nijs, L. Segal, A. Stecher, B. Vandamme, E. van Roosendaal, R. Schoysman, Intracytoplasmic injection of spermatids retrieved from testicular tissue: influence of testicular pathology, type of selected spermatids and oocyte activation. Human Reproduction. ,vol. 12, pp. 1203- 1213 ,(1997) , 10.1093/HUMREP/12.6.1203
S. Fishel, S. Green, A. Hunter, F. Lisi, L. Rinaldi, R. Lisi, H. McDermott, Human fertilization with round and elongated spermatids. Human Reproduction. ,vol. 12, pp. 336- 340 ,(1997) , 10.1093/HUMREP/12.2.336
J. Tesarik, F. Rolet, C. Brami, E. Sedbon, J. Thorel, C. Tibi, A. Thebault, Spermatid injection into human oocytes. II.Clinical application in the treatment of infertility due to non obstructive azoospermia Human Reproduction. ,vol. 11, pp. 780- 783 ,(1996) , 10.1093/OXFORDJOURNALS.HUMREP.A019254