Radiation therapy versus pelvic node resection for carcinoma of the vulva with positive groin nodes.

摘要: From 1977 to 1984, 114 eligible patients with invasive squamous cell carcinoma of the vulva and positive groin nodes after radical vulvectomy bilateral lymphadenectomy were randomized receive either radiation therapy or pelvic node resection. Fifty-three 59 received a 4500- 5000-rad tumor dose in five 6.5 weeks bilaterally groins midplane pelvis even if only unilateral had been detected; no was given central vulvar area. 55 further surgery resection performed on side containing unilaterally bilaterally. Acute chronic morbidity similar for both regimens. The two major poor prognostic factors clinically suspicious fixed ulcerated more nodes. difference survival evaluable significant, favoring adjunctive group (P = .03). estimated two-year rates 68% 54% group. most dramatic advantage who present; at this time, benefit remaining is uncertain. In prospective study, addition irradiation inguinal proved superior