Free radical induced oxidative damage to DNA: relation to brain aging and neurological disorders.

摘要: Free radicals are produced in cells by cellular metabolism and exogenous agents. These species react with biomolecules one of the important targets is DNA. This kind damage, often referred to as oxidative DNA has consequences various organs particularly brain, view its high metabolic activity oxygen consumption. The include mutagenesis kinds ranging from simple oxidation bases large deletions through single double strand breaks. In because post-mitotic nature, damage seen more at level bases. A major route for repairing base excision repair (BER). It increasingly becoming apparent that defects can lead a number neurological disorders like Alzheimer Parkinson. Our recent studies have clearly demonstrated BER highly compromised brain increasing age this could well be causative factors normal aging associated deteriorating mental conditions, including certain abnormalities.