Antioxidant action of Moringa oleifera Lam. (drumstick) against antitubercular drugs induced lipid peroxidation in rats.
作者： N. Ashok Kumar , L. Pari
DOI: 10.1089/10966200360716670
关键词: Superoxide dismutase 、 Catalase 、 Biochemistry 、 Glutathione peroxidase 、 Chemistry 、 Pharmacology 、 Moringa 、 Vitamin C 、 Glutathione 、 Lipid peroxidation 、 Antioxidant
摘要: The protective effect of Moringa oleifera Lam. (Moringaceae) on hepatic marker enzymes, lipid peroxidation, and antioxidants was investigated during antitubercular drug (isoniazid, rifampicin, pyrazinamide)-induced toxicity in rats. Enhanced enzymes peroxidation treatment accompanied by a significant decrease the levels vitamin C, reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, S-transferase. Administration extract silymarin significantly decreased with simultaneous increase level antioxidants. We speculate that exerts its effects decreasing liver peroxides enhancing
liebertonline.com参考文章(45)
Frans A. Kuypers, Bertram H. Lubin, Mark D. Scott, Lin Zuo, Erythrocyte defense against hydrogen peroxide: preeminent importance of catalase. Journal of Laboratory and Clinical Medicine. ,vol. 118, pp. 7- 16 ,(1991) , 10.5555/URI:PII:002221439190110S
King Ej, Armstrong Ar, A CONVENIENT METHOD FOR DETERMINING SERUM AND BILE PHOSPHATASE ACTIVITY. Canadian Medical Association Journal. ,vol. 31, pp. 376- 381 ,(1934)
Skakun Np, Slivka IuI, The correction of the hepatotoxicity of antitubercular preparations with tocopherol acetate and riboxin Eksperimental'naia i klinicheskaia farmakologiia. ,vol. 55, pp. 52- 54 ,(1992)
Devi Cs Shyamala, SD Saraswathy, V Suja, Gurumurthy Prema, Effect of Liv.100 against antitubercular drugs (isoniazid, rifampicin and pyrazinamide) induced hepatotoxicity in rats Indian Journal of Pharmacology. ,vol. 30, pp. 233- 238 ,(1998)
Vanisha S. Nambiar, Subadra Seshadri, Bioavailability trials of β-carotene from fresh and dehydrated drumstick leaves ( Moringa oleifera ) in a rat model Plant Foods for Human Nutrition. ,vol. 56, pp. 83- 95 ,(2001) , 10.1023/A:1008132503972
William H. Habig, Michael J. Pabst, William B. Jakoby, Glutathione S-Transferases Journal of Biological Chemistry. ,vol. 249, pp. 7130- 7139 ,(1974) , 10.1016/S0021-9258(19)42083-8
P N Viswanathan, Poonam Kakkar, Ballabh Das, A modified spectrophotometric assay of superoxide dismutase. Indian Journal of Biochemistry & Biophysics. ,vol. 21, pp. 130- 132 ,(1984)
G Ramellini, J Meldolesi, Liver protection by silymarin: in vitro effect on dissociated rat hepatocytes. Drug Research. ,vol. 26, pp. 69- 73 ,(1976)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Alton Meister, William C. Rose: Lectureship in Biochemistry and Nutrition Nutrition Reviews. ,vol. 42, pp. 397- 410 ,(2009) , 10.1111/J.1753-4887.1984.TB02277.X