Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma
作者： Ali Bahrami-Samani , Amir Reza Jalilian , Mohammad Ghannadi-Maragheh , Hassan Yousefnia , Mohammad Mazidi
DOI:
关键词: Hepatocellular carcinoma 、 Post injection 、 Nuclear medicine 、 Medicine 、 Chitosan 、 Holmium 166 、 Human use 、 Normal tissue 、 Injection site 、 Venography 、 Pathology
摘要: Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment tumors such as hepatocellular carcinoma. This has been lately prepared with high radiochemical purity in our lab. The preclinical studies however should be performed evaluate tracer concentration target normal tissues before human use. Methods:In this study, its carcinoma carried out by injection radiopharmaceutical into rabbit`s liver via two different methods, surgery venography. Leakage injected activity from site rabbit organs investigated using SPECT SPECT-CT imaging up 24 hours. Results:Both rabbits showed that there no significant leakage activity. Almost all would remain at least h post injection. Conclusion: Considering excellent features complex, is suggestive radioembolization method.
参考文章(13)
Josep M Llovet, Jordi Bruix, Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival Hepatology. ,vol. 37, pp. 429- 442 ,(2003) , 10.1053/JHEP.2003.50047
W-Y Lau, W-T Leung, S Ho, NWY Leung, M Chan, J Lin, C Metreweli, P Johnson, AKC Li, Treatment of inoperable hepatocellular carcinoma with intrahepatic arterial yttrium-90 microspheres: a phase I and II study British Journal of Cancer. ,vol. 70, pp. 994- 999 ,(1994) , 10.1038/BJC.1994.436
George Sgouros, Robert F. Hobbs, Diane S. Abou, The role of preclinical models in radiopharmaceutical therapy. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. ,vol. 34, pp. 121- 125 ,(2014) , 10.14694/EDBOOK_AM.2014.34.E121
J Raoul, D Guyader, J Bretagne, J Heautot, R Duvauferrier, P Bourguet, D Bekhechi, Y M Deugnier, M Gosselin, Prospective randomized trial of chemoembolization versus intra-arterial injection of 131I-labeled-iodized oil in the treatment of hepatocellular carcinoma. Hepatology. ,vol. 26, pp. 1156- 1161 ,(1997) , 10.1002/HEP.510260511
J.K. Kim, K.H. Han, J.T. Lee, C.Y. Chon, Y.M. Moon, Y.H. Paik, The long term therapeutic efficacy and the safety of percutaneous holmium injection for the treatment of small hepatocellular carcinoma Journal of Hepatology. ,vol. 38, pp. 6- ,(2003) , 10.1016/S0168-8278(03)80430-0
B.C. Shin, K.B. Park, B.S. Jang, S.M. Lim, C.K. Shim, Preparation of 153Sm-Chitosan Complex for radiation synovectomy Nuclear Medicine and Biology. ,vol. 28, pp. 719- 725 ,(2001) , 10.1016/S0969-8051(00)00211-0
FX Sundram, Radionuclide therapy of hepatocellular carcinoma. Biomedical Imaging and Intervention Journal. ,vol. 2, ,(2006) , 10.2349/BIIJ.2.3.E40
Seung Kyoo Seong, Jei Man Ryu, Dong Hyuk Shin, Eun Jeong Bae, Akiyo Shigematsu, Yasuhiko Hatori, Junko Nishigaki, Cheol Kwak, Sang Eun Lee, Kyong Bae Park, Biodistribution and excretion of radioactivity after the administration of 166Ho-chitosan complex (DW-166HC) into the prostate of rat. European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 32, pp. 910- 917 ,(2005) , 10.1007/S00259-005-1792-1
Ryoong Huh, Yong Sook Park, Jong Doo Lee, Young Sun Chung, Yong Gou Park, Sang Sup Chung, Jin Woo Chang, Therapeutic Effects of Holmium-166 Chitosan Complex in Rat Brain Tumor Model Yonsei Medical Journal. ,vol. 46, pp. 51- 60 ,(2005) , 10.3349/YMJ.2005.46.1.51
Sudipta Chakraborty, Tapas Das, Haladhar D. Sarma, Meera Venkatesh, Sharmila Banerjee, Preparation and preliminary studies on 177Lu-labeled hydroxyapatite particles for possible use in the therapy of liver cancer Nuclear Medicine and Biology. ,vol. 35, pp. 589- 597 ,(2008) , 10.1016/J.NUCMEDBIO.2008.03.003