NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer.
作者： Chi-Chou Huang , Wen-Pin Chien , Ruey-Hong Wong , Ya-Wen Cheng , Meng-Cheng Chen
DOI: 10.1002/EM.20444
关键词: Mutation (genetic algorithm) 、 Biology 、 RAS Mutation 、 Promoter methylation 、 Genotype 、 Fast acetylator 、 Internal medicine 、 Arylamine N-acetyltransferase 、 Colorectal cancer 、 Oncology 、 Genetics 、 Methylation
摘要: A recent study conducted by our group showed that the NAT2 fast acetylator genotype is associated with an increasing risk for development of colorectal cancer (CRC), especially females. We therefore examined whether a higher CRC in females was occurrence K-RAS mutation, and to further verify MGMT promoter methylation linked mutation patients genotype. Herein, 151 cases were genetic polymorphisms PCR-RFLP methylation-specific PCR (MSP). The results this show female (OR = 4.820, 95% CI 1.113–20.873), but not methylation. Surprisingly, significantly deepens impact acetylation on 5.129, 1.092–24.105). In conclusion, Taiwanese women may exhibit increased mutation. Detection genotypes be useful assessment women. Environ. Mol. Mutagen., 2009. © 2008 Wiley-Liss, Inc.
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