Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers
作者： Chris Pepper , Thet Thet Lin , Guy Pratt , Saman Hewamana , Paul Brennan
DOI: 10.1182/BLOOD-2008-05-157131
关键词: Chronic lymphocytic leukemia 、 In vivo 、 Immunology 、 Fludarabine 、 Hematology 、 Apoptosis 、 Cancer 、 In vitro 、 Biology 、 Cancer research 、 Internal medicine 、 Disease
摘要: Bcl-2 family proteins play a critical role in the regulation of apoptosis chronic lymphocytic leukemia (CLL). However, their association with established prognostic markers is unknown. In this study, we analyzed expression Bcl-2, Bax, and Mcl-1 185 CLL patients evaluated relationship other markers, vitro sensitivity to fludarabine, clinical outcome. was significantly correlated stage disease (P
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