Lysed enterococcus faecalis FK-23 oral administration reveals inverse association between tuberculin responses and clinical manifestations in perennial allergic rhinitis: a pilot study.

摘要: BACKGROUND The interest in anti-allergy immunoregulation by lactic acid bacteria (LAB) has been growing over the last few decades. There is evidence to suggest that lysed Enterococcus faecalis FK-23 (LFK), a kind of LAB preparation, could relieve clinical symptoms Japanese cedar pollinosis. However, little known about how LFK plays role combating allergy. OBJECTIVE aim this study was clarify whether improvement manifestations associated with enhancement tuberculin responses patients allergic rhinitis treated LFK. METHODS One gram per day administered orally fifty perennial an open trial lasted 28 days. Nasal and sign scores were rated before after administration Tuberculin peripheral blood cells also measured treatment. RESULTS Purified protein derivative (PPD) skin test diameter 2.14 +/- mm versus 7.26 4.81 at 31 (p < 0.01). A significant inverse correlation recognized between PPD diameters total nasal provocation treatment (r= - 0.600, p 0.001). Peripheral eosinophils 248 149 cells/ml then they significantly decreased 76 98 cells/microl CONCLUSIONS These finding may be interpreted as result improved oral owing enhanced host's Th1-type immune supression over-expression Th2-dominated responses.