Leptospirosis among patients presenting with dengue-like illness in Puerto Rico

摘要: Leptospirosis is difficult to distinguish from dengue fever without laboratory confirmation. Sporadic cases/clusters of leptospirosis occur in Puerto Rico, but surveillance passive and confirmation rare. We tested for using an IgM ELISA on sera testing negative virus antibody conducted a case-control study assessing risk factors leptospirosis, comparing clinical/laboratory findings between (case-patients) patients (controls). Among 730 dengue-negative sera, 36 (5%) were positive leptospirosis. performed post mortem 12 available specimens suspected dengue-related fatalities; 10 (83%) positive. these fatal cases, pulmonary hemorrhage renal failure the most common causes death. enrolled 42 case-patients 84 controls. Jaundice, elevated BUN, hyperbilirubinemia, anemia, leukocytosis associated with (p < .01 all). Male sex, walking puddles, rural habitation, owning horses independently Epidemiological, clinical, criteria may help identify who would benefit early antibiotic treatment.