Effects of unilateral cardiac sympathetic denervation on the ventricular fibrillation threshold

摘要: A train of gated stimuli scanning the entire vulnerable period was delivered to right anterior or left posterior ventricular surface study fibrillation threshold in anesthetized and vagotomized dogs. Heart rate held constant by atrial pacing. Measurements were obtained control conditions after surgical removal one stellate ganglion. To avoid shortcomings associated with an irreversible procedure like stellectomy, measurements also alternated determinations during reversible blockade cooling The results similar both techniques. In nine animals, ablation ganglion increased 72 ± 35 (mean standard deviation) percent compared values (P < 0.001). By contrast, 11 lowered 48 14 Electrode location did not influence results. observed changes depended solely upon unilateral cardiac sympathetic activity demonstrable if such low. These suggest that nerves may have different specific effects on excitability. They contribute understanding pathogenesis long Q-T syndrome (characterized episodes activity) increase rationale for stellectomy as treatment this illness. Left raising threshold, represent alternative measure patients at high risk sudden death from arrhythmias resistant medical therapy.