A possible mechanism of impaired NK cytotoxicity in cancer patients: Down-regulation of DAP10 by TGF-β1
作者： Dae Seog Heo , Kyung Mi Lee , June Chul Lee , Beomseok Suh , Yong Oon Ahn
DOI: 10.1700/912.10124
关键词: Secretion 、 NK Cell Lectin-Like Receptor Subfamily K 、 Downregulation and upregulation 、 Medicine 、 Cancer 、 NKG2D 、 Cytotoxicity 、 Interleukin 21 、 Immunosuppression 、 Immunology
摘要: Aims and backgroundElevated TGF-β1 secretion down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. However, the molecular mechanism immunosuppression by is n...
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