The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2
作者： Zhimin Lu , Shuichan Xu , Claudio Joazeiro , Melanie H Cobb , Tony Hunter
DOI: 10.1016/S1097-2765(02)00519-1
关键词: MAPK/ERK pathway 、 Kinase 、 Kinase activity 、 Biochemistry 、 Biology 、 Phosphorylation 、 Ubiquitin 、 Cell signaling 、 Protein kinase domain 、 Ubiquitin ligase
摘要: … ubiquitinated ERK1/… ubiquitination of ERK in vivo in a PHD domain-dependent manner. We conclude that MEKK1 acts as an adaptor-type E3 Ub ligase to promote ERK1/2 ubiquitination…
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