Rapid onset of argyria induced by a silver-containing dietary supplement.

摘要: We describe a 53-year-old man in good general health who presented with an 8-month history of progressive gray hyperpigmentation the face. He denied using any prescription medications; however, he admitted to taking herbal supplement. Clinically, differential diagnosis included hemochromatosis, Wilson's disease and secondary supplement use. Punch biopsies from left forehead preauricular region showed heavily sun-damaged skin minimal inflammatory infiltrate. Closer inspection, revealed minute scattered black/brown particles distributed basement membrane zone eccrine sebaceous glands. Similar were also present hair follicles, blood vessels arrector pili muscles. The did not stain Gomori methenamine silver, Fontana-Masson or iron stains. Electron microscopy energy-dispersive x-ray analysis numerous particles, less than 1 µm greatest dimension, which peaks for silver sulfur. This analytical result confirmed impression argyria. Further that patient had indeed been several months under premise it would boost his immune system. case is unique patient's developed short period time as compared other reports medical literature. Bowden LP, Royer MC, Hallman JR, Lewin-Smith M, Lupton GP. Rapid onset argyria induced by silver-containing dietary