Immunological and biochemical parameters of patients with metabolic syndrome and the participation of oxidative and nitroactive stress.
作者： ANC Simão , MAB Lozovoy , TNC Simão , D Venturini , DS Barbosa
DOI: 10.1590/S0100-879X2011007500069
关键词: Insulin resistance 、 Chemistry 、 Endocrinology 、 Nitric oxide 、 Adiponectin 、 Oxidative stress 、 Fibrinogen 、 Endothelial dysfunction 、 Internal medicine 、 Uric acid 、 Metabolic syndrome 、 Biochemistry
摘要: Abstract Metabolic syndrome (MS) is a multifactorial disease involving inflammatory activity and endothelial dysfunction. The aim of the present study was to evaluate relationship between changes in lipoperoxidation, immunological biochemi-cal parameters nitric oxide metabolite (NOx) levels MS patients. Fifty patients with (4 males/46 females) 50 controls (3 males/47 were studied. Compared control (Mann-Whitney test), presented higher serum (P < 0.05) fibrinogen: 314 (185-489) vs 262 (188-314) mg/dL, C-reactive protein (CRP): 7.80 (1.10-46.50) 0.70 (0.16-5.20) interleukin-6: 3.96 (3.04-28.18) 3.33 (2.55-9.63) pg/mL, uric acid: 5.45 (3.15-9.65) 3.81 (2.70-5.90) hydroperoxides: 20,689 (19,076-67,182) 18,636 (15,926-19,731) cpm. In contrast, they lower adiponectin: 7.11 (3.19-18.22) 12.31 (9.11-27.27) µg/mL, NOx levels: 5.69 (2.36-8.18) 6.72 (5.14-12.43) µM. inversely associated (Spearman’s rank correlation) body mass index (r = -0.2858, P 0.0191), insulin resistance determined by homeostasis model assessment -0.2530, 0.0315), CRP -0.2843, 0.0171) fibrinogen -0.2464, 0.0413), positively correlated hydroperoxides 0.2506, 0.0408). conclusion, are obesity, resistance, oxidative stress, markers. high acid together reactive oxygen species generation may be responsible for reduced NO levels, which turn lead dysfunc-tion. elevated plasma chemiluminescence reflecting both increased oxidation antioxidant capacity play role mechanism.Key words: syndrome; Uric acid; Inflammation; Adiponectin; Nitric oxide; Lipoperoxidation
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