Association between polymorphisms in genes involved in lipid metabolism and immunological status in chronically HIV-infected patients

摘要: Several studies have reported associations between lipid parameters and clinical progression of HIV infection. We performed a cross-sectional study including 468 antiretroviral-treated HIV-infected patients to investigate the impact 13 polymorphisms 9 genes affecting metabolism CD4 CD8-T cell levels. Polymorphisms were identified in selected for their role development atherogenic dyslipidemia, defined as triglycerides ⩾1.7mmol/L high-density lipoprotein cholesterol (HDLc) <1.02 women or 1.28mmol/L men. Lipid determined all participants, well CD8 T-cell counts. ANOVA was compare mean values count data. A Bonferroni correction multiple comparisons applied. included, 148 them had diagnosis dyslipidemia. The polymorphism rs3135506 APOA5 associated with 9% increase (p=0.002), 10% 21% decrease HDLc (p=0.005), (p=0.024), respectively. rs662799, 19% (p=0.002). Carriers LPL rs328 dyslipidemic group presented 11% higher levels (p=0.015) 14% cells (p=0.038). In conclusion, especially variants gene (rs3135506 rs662799), can influence circulating chronically patients. These data support previous reports on effect immunologic HIV+ individuals antiretroviral therapy.