High particle variability across siliconized and oil-free syringes and needles from the same lots

摘要: Previous studies have reported silicone oil (SO) applied to needles and syringes in the vitreous of patients after intravitreal injections. We evaluated four (SR 1-mL insulin, Saldanha-Rodrigues; BD Tuberculin Slip Tip, Becton-Dickinson; Ultra-Fine 0.3 mL, HSW Norm-Ject Tuberculin, Henke Sass Wolf) 10 (BD PrecisionGlide 27- 30-gauge (G); Eclipse JBP Nanoneedle 27-, 30-, 33- 34-G; TSK Invisible Needle 27 30-G Steriject Control Hub). The protein-free buffer samples injected into under study were collected an Eppendorf tube taken Flow imaging microscopy, that characterized concentration morphology microsized particles. number particles was analyzed. coefficients variation (CV) primary outcome. Feltz Miller test compared CVs. significance level 5%. Numerous high CVs associated with both devices, syringes; comparisons among them did not reach significance. Ultrafine 0.3 mL syringe (149.7%) had highest CV SO-free (66.4%) lowest, needle (149.5%) Precision Glide 30G (35.9%) lowest. In conclusion, particle release, including those SO morphology, varied greatly instruments, even from same lots, which is relevant considering fewer are some eyes others.