Physiological modeling of isoprene dynamics in exhaled breath

摘要: Human breath contains a myriad of endogenous volatile organic compounds (VOCs) which are reflective ongoing metabolic or physiological processes. While research into the diagnostic potential and general medical relevance these trace gases is conducted on considerable scale, little focus has been given so far to sound analysis quantitative relationships between levels underlying systemic concentrations. This paper devoted thorough modeling study end-tidal dynamics associated with isoprene, serves as paradigmatic example for class low-soluble, blood-borne VOCs. Real-time measurements exhaled under an ergometer challenge reveal characteristic changes isoprene output in response variations ventilation perfusion. Here, valid compartmental description profiles developed. By comparison experimental data it inferred that major part variability during exercise conditions can be attributed increased fractional perfusion storage production sites, leading higher mixed venous blood concentrations at onset physical activity. In this context, various lines supportive evidence extrahepatic tissue source presented. Our model first step towards new guidelines gas expected aid further investigations regarding exhalation, storage, transport biotransformation processes important compound.