β CELLS IN PANCREATIC ISLETS AND GLUCOSE REGULATION

作者: J Jo , H Kang , MY Choi , D-S Koh , None

DOI: 10.1142/S021797920704527X

关键词: Insulin secretionBiophysicsInsulin oscillationCoupling (electronics)CalciumPancreatic isletsBlood sugar regulationGap junctionChemistryBursting

摘要: We present a model for oscillatory behaviors of β cells in pancreatic islets and glucose regulation. With attention to the noise induced by channel-gating stochasticity coupling via gap junctions, we obtain extensive numerical simulations complex oscillations including clusters bursting action potentials, slow fast calcium insulin secretion, so on.

参考文章(11)
T.A. Kinard, G. de Vries, A. Sherman, L.S. Satin, Modulation of the Bursting Properties of Single Mouse Pancreatic β-Cells by Artificial Conductances Biophysical Journal. ,vol. 76, pp. 1423- 1435 ,(1999) , 10.1016/S0006-3495(99)77303-0
S. Göpel, T. Kanno, S. Barg, J. Galvanovskis, P. Rorsman, Voltage‐gated and resting membrane currents recorded from B‐cells in intact mouse pancreatic islets The Journal of Physiology. ,vol. 521, pp. 717- 728 ,(1999) , 10.1111/J.1469-7793.1999.00717.X
L. Chen, D.-S. Koh, B. Hille, Dynamics of Calcium Clearance in Mouse Pancreatic β-Cells Diabetes. ,vol. 52, pp. 1723- 1731 ,(2003) , 10.2337/DIABETES.52.7.1723
P. Smolen, J. Rinzel, A. Sherman, Why pancreatic islets burst but single beta cells do not. The heterogeneity hypothesis Biophysical Journal. ,vol. 64, pp. 1668- 1680 ,(1993) , 10.1016/S0006-3495(93)81539-X
GERDA DE VRIES, ARTHUR SHERMAN, Channel Sharing in Pancreatic β -Cells Revisited: Enhancement of Emergent Bursting by Noise Journal of Theoretical Biology. ,vol. 207, pp. 513- 530 ,(2000) , 10.1006/JTBI.2000.2193
Bernat Soria, Etel Andreu, Genoveva Berná, Esther Fuentes, Amparo Gil, Trinidad León-Quinto, Franz Martín, Eduard Montanya, Angel Nadal, Juan A. Reig, Cristina Ripoll, Enrique Roche, Juan V. Sanchez-Andrés, Javier Segura, Engineering pancreatic islets. Pflügers Archiv: European Journal of Physiology. ,vol. 440, pp. 1- 18 ,(2000) , 10.1007/S004240000251
Junghyo Jo, Hyuk Kang, Moo Young Choi, Duk-Su Koh, None, How Noise and Coupling Induce Bursting Action Potentials in Pancreatic β-Cells Biophysical Journal. ,vol. 89, pp. 1534- 1542 ,(2005) , 10.1529/BIOPHYSJ.104.053181
Frances M. Ashcroft, Peter Proks, Paul A. Smith, Carina Ämmälä, Krister Bokvist, Patrik Rorsman, Stimulus-secretion coupling in pancreatic beta cells. Journal of Cellular Biochemistry. ,vol. 55, pp. 54- 65 ,(1994) , 10.1002/JCB.240550007
H. Kang, J. Jo, H. J. Kim, M. Y. Choi, S. W. Rhee, D. S. Koh, Glucose metabolism and oscillatory behavior of pancreatic islets Physical Review E. ,vol. 72, pp. 051905- ,(2005) , 10.1103/PHYSREVE.72.051905
P. Rorsman, E. Renstr�m, Insulin granule dynamics in pancreatic beta cells. Diabetologia. ,vol. 46, pp. 1029- 1045 ,(2003) , 10.1007/S00125-003-1153-1