C4d Immunohistochemistry in glomerulonephritis with different antibodies.
作者： Taisei Suzuki , Shigeru Horita , Koji Kadoya , Koji Mitsuiki , Kumi Aita
DOI: 10.1007/S10157-007-0496-1
关键词: Pathology 、 Immunohistochemistry 、 Staining 、 Molecular biology 、 Immunofluorescence 、 Biology 、 Polyclonal antibodies 、 Frozen section procedure 、 Immunoperoxidase 、 Monoclonal antibody 、 Monoclonal
摘要: Background The presence of C4d in the kidney is generally detected particularly for diagnosis antibody-mediated rejection renal transplants. In frozen sections immunofluorescence (IF) staining with anti-C4d monoclonal antibodies (mAbs), we noted intrinsic deposition even normal glomeruli though their pathogenic or an role unkown. An polyclonal antibody (C4dpAb), which suitable paraffin immunoperoxidase (IP) staining, less used than mAbs, and it has demonstrated that not evident. To establish a stable reproducible procedure detection C4dpAb to determine characteristics it, present study aimed test whether method was comparable IF mAb.
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