Evidence of bias and variation in diagnostic accuracy studies
作者： Anne WS Rutjes , Johannes B Reitsma , Marcello Di Nisio , Nynke Smidt , Jeroen C Van Rijn
DOI: 10.1503/CMAJ.050090
关键词: MEDLINE 、 Medical test 、 Diagnostic odds ratio 、 Variance (accounting) 、 Statistics 、 Research design 、 Cohort 、 Pathology 、 Medicine 、 Confidence interval 、 Regression analysis
摘要: Background: Studies with methodologic shortcomings can overestimate the accuracy of a medical test. We sought to determine and compare the direction and magnitude of the effects of a number of potential sources of bias and variation in studies on estimates of diagnostic accuracy. Methods: We identified meta-analyses of the diagnostic accuracy of tests through an electronic search of the databases MEDLINE, EMBASE, DARE and MEDION (1999–2002). We included meta-analyses with at least 10 primary studies without …
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