Familial Pyrimidinemia and Pyrimidinuria Associated with Severe Fluorouracil Toxicity
作者： Mendel Tuchman , Joel S. Stoeckeler , David T. Kiang , Robert F. O'Dea , Margaret L. Ramnaraine
DOI: 10.1056/NEJM198507253130407
关键词: Fluorouracil 、 Antimetabolite 、 Pyrimidine 、 Dihydropyrimidine dehydrogenase deficiency 、 Medicine 、 Pyrimidine metabolism 、 Toxicity 、 DNA 、 Pharmacology 、 RNA 、 General Medicine
摘要: RAPIDLY growing tumor cells depend on a high rate of pyrimidine synthesis for the generation RNA and DNA. Fluorouracil is pyrimidine-base analogue that acts as an antimetabolite to block s...
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