作者: Khushbu Singh , Payal Srivastava , Ashis K. Patra
DOI: 10.1016/J.ICA.2016.07.003
关键词: Chemistry 、 Denticity 、 Lanthanide 、 Isothermal titration calorimetry 、 Stereochemistry 、 Quinoxaline 、 Binding constant 、 Bovine serum albumin 、 Ligand (biochemistry) 、 Coordination geometry
摘要: Abstract Two new lanthanide(III) complexes [Ln(dpq)(DMF)2(NO3)3], where Ln = Pr (1), Nd (2), dpq = dipyrido[3,2-d:2′,3′-f]quinoxaline, DMF = N,N-dimethylformamide were synthesized, characterized by various spectroscopic methods and single crystal X-ray crystallography. They studied for their DNA protein binding photo-induced cleavage activity. The displays ten-coordinate [LnN2O8] bicapped dodecahedron coordination geometry from a bidentate N,N-donor dpq ligand, two DMF three NO 3 - anions. 1 2 showed intense ligand centered absorption bands ∼300–350 nm originated n/π → π∗ transition dipyridoquinoxaline (dpq). interaction of with UV–vis spectroscopy, competitive displacement ethidium bromide isothermal titration calorimetry (ITC) shows that the display efficient affinity to calf thymus constant (Kb) ∼104 M−1 suggesting groove or partial intercalation CT-DNA. favorable bovine serum albumin (BSA) (KBSA) ∼105 M−1. Both efficiently cleave supercoiled (SC) its nicked circular (NC) form at UV-A light 365 nm 10 μM via formation singlet oxygen (1O2) hydroxyl radical ( OH) species under physiological condition in type-II photoredox pathway.