Plastics derived endocrine-disrupting compounds and their effects on early development.

摘要: Despite the fact that estrogenic effects of bisphenols were first described 80 years ago, recent data about its potential negative impact on birth outcome parameters raises a strong rationale to investigate further. The adverse health plastics recommend measure impacts endocrine-disrupting compounds (EDCs) such as (BPA, BPS, BPF), bis(2-ethylhexyl) phthalate, and dibutyl phthalate (DBP) in human health. Exposure these utero may program diseases testis, prostate, kidney abnormalities immune system, cause tumors, uterine hemorrhage during pregnancy polycystic ovary. These also control processes epigenetic transgenerational inheritance adult-onset by modulating DNA methylation epimutations reproductive cells. early developmental stage is most susceptible window for genomic programming. critical stages events normal lie between many transitions occurring spermatogenesis, egg fertilization fully formed fetus. As cells begin grow differentiate, there are balances hormones, protein synthesis. Data emerging how plastic-derived affect embryogenesis, placentation feto-placental development since pregnant women unborn fetuses often exposed factors preconception throughout gestation. Impaired ultimately influences fetal outcomes at center disorders contributes an independent risk factor adult chronic diseases. This review will summarize current status exposure plastic derived EDCs growth, gene expression, angiogenic activities process their possible outcomes.