A rare allele combination of the interleukin-1 gene complex is associated with high interleukin-1b plasma levels in healthy individuals.
作者： J. Hulkkonen , M. Hurne , P. Laippala
DOI:
关键词: Antagonist 、 Interleukin 1 family 、 Inflammation 、 Immunology 、 Gene 、 Cell 、 Receptor 、 Biology 、 Allele 、 Inducer
摘要: INTRODUCTION The inflammatory reaction in infectious and autoimmune diseases is regulated by a delicate balance between the pro-inflammatory anti-inflammatory cytokines. IL-1 gene complex contains genes for IL-1alpha, IL-1beta IL-1Ra, of which first two are strong inducers inflammation, while IL-1Ra binds to receptors with high affinity without activating cell, thus being an effective antagonist (for [...]
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