Lability of the trifluoromethyl group of trifluoromethoxybenzenes under HF/Lewis acid conditions
作者： Randolph K. Belter
DOI: 10.1016/J.JFLUCHEM.2010.08.003
关键词: Chemistry 、 Friedel–Crafts reaction 、 Lewis acids and bases 、 Medicinal chemistry 、 Group (periodic table) 、 Phenyl Ethers 、 Trifluoromethyl 、 Fries rearrangement 、 Lability 、 Lewis acid catalysis 、 Organic chemistry
摘要: Abstract The trifluoromethyl functionality of trifluoromethoxybenzenes (trifluoromethyl phenyl ethers) becomes labile under HF/Lewis acid conditions. Substrates with an unsubstituted para-position shed their –CF 3 groups while performing a Friedel–Crafts reaction upon another substrate molecule's trifluoromethoxy group to generate p -rosolic acids. that had blocking at the para-positions reacted ortho. electron donating substituents methoxy and phenoxy interfered formation rosolic
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