Periodontal disease and risk of subsequent cardiovascular disease in U.S. male physicians

摘要: OBJECTIVES We sought to prospectively assess whether self-reported periodontal disease is associated with subsequent risk of cardiovascular in a large population male physicians. BACKGROUND Periodontal disease, the result complex interplay bacterial infection and chronic inflammation, has been suggested be predictor disease. METHODS Physicians' Health Study I was randomized, double-blind, placebo-controlled trial aspirin beta-carotene 22,071 U.S. A total 22,037 physicians provided self-reports presence or absence at study entry were included this analysis. RESULTS 2,653 reported personal history baseline. During an average 12.3 years follow-up, there 797 nonfatal myocardial infarctions, 631 strokes 614 deaths. Thus, for each end point, had >90% power detect clinically important increased 50%. In Cox proportional hazards regression analysis adjusted age treatment assignment, who baseline slightly elevated, but statistically nonsignificant, relative risks (RR) infarction, (RR, 1.12; 95% confidence interval [CI], 0.92 1.36), stroke 1.10; CI, 0.88 1.37) death 1.20; 0.97 1.49). Relative combined point all events (first occurrence death) 1.13 (CI, 0.99 1.28). After adjustment other factors, RRs attenuated nonsignificant. CONCLUSIONS These prospective data suggest that not independent middle-aged elderly men.