Autoimmune polyendocrine syndrome type 1 (APS‐1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS‐2)

摘要: Autoimmune polyendocrine syndromes type 1 and 2 (APS-1 APS-2) are diverse in regards to their component diseases immunologic features of pathogenesis. Animal models human studies highlight the importance alleles HLA (human leukocyte antigen)-like molecules determining tissue specific targeting that with loss tolerance leads organ autoimmunity. Knowledge allows clinicians recognize prevent illness prior morbidity. With current understanding syndromes, a paradigm for diagnosis, screening treatment can be established. Once genetically susceptible individuals identified autoantibodies performed. Amongst autoantibody positive individuals, monitoring physiologic decompensation, goal treating morbidity some cases mortality, follows. continued basic clinical research, therapies aimed at underlying autoimmunity disease prevention should become possible.