PD-1/PD-L1 as a prognostic factor in leukemia

摘要: PD-1 receptor is a component of the immune system that recognized as negative regulator responses together with its ligand (PD-L1). In this study, we review role in leukemia cells through and ligand. Relevant literature was identified by Pubmed search (1994–2017) English-language papers using terms “PD-1”, “PD-L1”, “leukemia”, “prognosis”. an inhibitory CD28 family. Although initially introduced driving factor apoptosis activated T cells, pre-clinical studies revealed importance molecule checkpoint ambient tolerance system. The widely expressed on malignant inhibits cytotoxic cells. Therefore, targeting PD-1/PD-L1 can sensitize to chemotherapy increase patient’s survival therapeutic approach. Recently, immunotherapy has shown promising results antibodies against different cancers, it hoped application these combination other treatments (including chemotherapy) could inhibit improve conditions.