Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth

摘要: Inflammation contributes to nearly 4 million global premature births annually. Here, we used a mouse model of intrauterine inflammation test clinically formulations, as well engineered nanoformulations, for the prevention preterm birth (PTB). We observed that neither systemic 17a-hydroxyprogesterone caproate (Makena) nor vaginal progesterone gel (Crinone) was sufficient prevent inflammation-induced PTB, consistent with recent clinical trial failures. However, found delivery mucoinert nanosuspensions histone deacetylase (HDAC) inhibitors, in some cases addition progesterone, prevented PTB and resulted live pups exhibiting neurotypical development. In human myometrial cells vitro, P4/HDAC inhibitor combination both inhibited cell contractility promoted anti-inflammatory action P4 by increasing receptor B stability. demonstrate use vaginally delivered drugs resulting offspring preclinical animal model.