A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.

摘要: Many human melanoma tumors express antigens that are recognized in vitro by cytolytic T lymphocytes (CTLs) derived from the tumor-bearing patient. A gene was identified directed expression of antigen MZ2-E on a cell line. This shows no similarity to known sequences and belongs family at least three genes. It is expressed original cells, other lines, some tumor cells histological types. No observed panel normal tissues. Antigen appears be presented HLA-A1; anti-MZ2-E CTLs patient two lines HLA-A1 patients gene. Thus, precisely targeted immunotherapy against could provided individuals HLA typing analysis RNA small sample.