Lithium Carbonate and Imipramine in Prevention of Affective Episodes

摘要: Patients with recurrent affective illness (N-122) were randomly assigned to lithium carbonate, imipramine, or placebo therapy for two years following discharge from hospitalization acute depression. classified as bipolar unipolar based on the presence absence of a history mania. With patients carbonate was significantly more effective than imipramine in preventing episodes (ie, manic depressive attacks severe enough require use nonstudy drugs). There relatively high incidence imipramine. Unipolar responded equally well Both treatments placebo. The difference between due primarily episodes; occurred infrequently and evenly distributed across treatment groups. no significant among patients.