Cardiovascular and Renal Toxicity of a Nonionic Radiographic Contrast Agent after Cardiac Catheterization

摘要: Study objective To determine the incidence of cardiovascular and renal toxicity a nonionic contrast agent when used for cardiac catheterization, to assess value electrolytes urinalysis results as predictors nephropathy induced by agent. design Nonrandomized trial using criterion standard cohort analytic study with 48-hour follow-up. Setting Referral-based university hospital. Patients Convenience sample patients having diagnostic catheterization. Renal function clinical status were evaluated at baseline in 1,144 patients; 24 hours 1,077 (94%); 48 663 (57%). Interventions After received saline hydration, coronary angiography left ventriculography done iopamidol (average dose, 203 +/- 56 cc). Measurements main The definite possible major acute complications from media was 0.2% 0.7%, respectively. mean serum creatinine level increased 11.5 mumol/L (P less than 0.0001) 16.8 0.0001). Results randomly selected training studied rise 44.2 or more. age significant injury, but hypertension, diabetes mellitus, congestive heart failure, vascular disease, volume injected values urinary variables did not predict nephrotoxicity. In an independent validation sample, only confirmed predictor nephrotoxicity, whereas not. A model that predicted contrast-induced showed exponential increase risk nephrotoxicity if 106.1 higher. Conclusions have small after catheterization Baseline insufficiency is