Synthesis of several novel 14-membered ketolides bearing modified 5-O-4′-[1,2,3] triazol desosamine side chain
作者： Xiaozhuo Chen , Yanpeng Xu , Zhehui Zhao , Pingsheng Lei
DOI: 10.1016/J.TETLET.2014.09.064
关键词: Stereochemistry 、 Desosamine 、 Alkyne 、 Click chemistry 、 Chemistry 、 Azide 、 Glycosylation 、 Ketolide 、 Side chain 、 Combinatorial chemistry
摘要: Abstract 4-Azido modified desosamine 4a was synthesized and coupled to erythronolide 9 . Using trichloroacetimidate donor in the presence of TMSOTf considered as most efficient condition for glycosylation reaction. Five novel 14-membered ketolides 12a – e bearing 5- O -4′-[1,2,3] triazol side chain were by azide/alkyne click chemistry method.
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