Histologic Patterns of Hepatotoxic Injury

作者: J.M. Cullen

DOI: 10.1016/B978-0-08-046884-6.01007-1

关键词: Cytochrome P450ApoptosisDegeneration (medical)CholestasisNecrosisSteatosisBile ductPeroxisome ProliferationPathologyMedicine

摘要: This chapter describes and illustrates the histologic manifestations of adaptive degenerative hepatic responses to injurious drugs chemicals in humans animals. The appearance changes such as cytochrome P450 induction peroxisome proliferation hepatocytes is described, well patterns degeneration necrosis. also alterations biliary epithelium cholestasis, reviews vascular disorders, discusses preneoplastic neoplastic lesions.

参考文章(267)
G R Hennigar, K R McMaster rd, Drug-induced granulomatous hepatitis. Laboratory Investigation. ,vol. 44, pp. 61- 73 ,(1981)
J Rodés, M Bernet, C Lamar, M Bruguera, Hepatic disease associated with ground-glass inclusions in hepatocytes after cyanamide therapy. Archives of Pathology & Laboratory Medicine. ,vol. 110, pp. 906- 910 ,(1986)
Martin Black, Jerry R. Mitchell, Hyman J. Zimmerman, Kamal G. Ishak, Gary R. Epler, Isoniazid-associated hepatitis in 114 patients. Gastroenterology. ,vol. 69, pp. 289- 302 ,(1975) , 10.1016/S0016-5085(19)32568-5
Renate Lüllmann-Rauch, Dorothea Scheid, Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs. Virchows Archiv B Cell Pathology. ,vol. 19, pp. 255- 268 ,(1975) , 10.1007/BF02889372
Kosek J, Nadell J, Peliosis hepatis. Twelve cases associated with oral androgen therapy. Archives of Pathology & Laboratory Medicine. ,vol. 101, pp. 405- ,(1977)
T. Kaku, R. H. Ho, M. Tatematsu, E. Farber, J. K. Ekem, Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy. American Journal of Pathology. ,vol. 114, pp. 418- 430 ,(1984)
J J Vázquez, Ground-glass hepatocytes: light and electron microscopy. Characterization of the different types. Histology and Histopathology. ,vol. 5, pp. 379- 386 ,(1990)
V. Jagic, D. Sabolovic, M. Rados, F. Culo, A. Bilic, M. Renic, Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. European Journal of Gastroenterology & Hepatology. ,vol. 7, pp. 757- 762 ,(1995)
Hyman J. Zimmerman, James H. Lewis, Chemical- and toxin-induced hepatotoxicity. Gastroenterology Clinics of North America. ,vol. 24, pp. 1027- 1045 ,(1995) , 10.1016/S0889-8553(21)00239-9
KG Ishak, VV Joshi, FG Mullick, C Daeschner, Jr Jr Modzelewski, Veno-occlusive disease of the liver induced by low-dose cyclophosphamide. Modern Pathology. ,vol. 7, pp. 967- 972 ,(1994)