Mitochondrial DNA abnormalities in NAION.

摘要: We reported that a group of 19 patients with non-arteritic ischaemic optic neuropathy (NAION) had an increased number mitochondrial (mt) DNA nucleotide changes1 and significantly relative mtDNA content compared to age sex matched controls.2 were pleased Carelli Sadun thought our most recent manuscript in BJO warranted editorial response.3 In this letter, we clarify data about changes NAION. Referring first report, they stated “… the polymorphisms found NAION are ancient, well known variants defining specific haplogroups (mtDNA maternal lineages) …