Is Ultra-Rapid Opioid Detoxification a Viable Option in the Treatment of Opioid Dependence?

摘要: Ultra-rapid opioid detoxification (UROD) involves the acceleration of withdrawal by administering receptor antagonist naltrexone under general anaesthesia. There is evidence from uncontrolled and a few controlled studies that UROD accelerates it achieves high rates completion acute withdrawal. However, there clear use anaesthetic not required to accelerate or achieve These goals can be achieved using naloxone light sedation, procedure known as rapid sedation (ROD). also an rate The mixed agonist-antagonist buprenorphine has comparable in similarly selected patients with fewer symptoms. no trials either ROD increases abstinence opioids 6 12 months after may increase number who are inducted onto maintenance (NM) therapy but extensive experience NM suggests only limited role patients. Given lack substantially increased abstinence, need for anaesthetists dependency beds, at best very minor treatment handful dependent unable complete withdraw any other way. have more one option well motivated want rapidly enter types abstinence-oriented treatment.