ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity.

摘要: Adipose tissue contains one of the largest reservoirs cholesterol in body. Adipocyte dysfunction obesity is associated with intracellular accumulation, and alterations homeostasis have been shown to alter glucose metabolism cultured adipocytes. ABCA1 plays a major role efflux, suggesting for maintaining adipocyte. However, impact adipocyte on adipose function unknown. Our aim was determine lipid metabolism, body weight, vivo. To address this, we used mice lacking specifically adipocytes (ABCA1−ad/−ad). When fed high-fat, high-cholesterol diet, ABCA1−ad/−ad showed increased triglyceride stores tissue, developed enlarged fat pads, had weight. Associated these phenotypic changes, observed significant changes expression genes involved homeostasis, including ldlr, abcg1, glut-4, adiponectin, leptin. also demonstrated impaired tolerance, lower insulin sensitivity, decreased secretion. We conclude that influences whole-body homeostasis.