Male pattern baldness in relation to prostate cancer risks: an analysis in the VITamins and lifestyle (VITAL) cohort study.

摘要: BACKGROUND Male pattern baldness and prostate cancer may share common pathophysiological mechanisms in terms of advancing age, heritability, endogenous hormones. Results from previous epidemiologic studies are inconsistent. Therefore, we investigated the association risks with male at age 30 years, 45 baseline (median age = 60.5 years) VITamins And Lifestyle (VITAL) cohort study. METHODS We included 32,583 men who were aged 50–76 years without prior diagnosis (excluding non-melanoma skin cancer) start follow-up. First primary incident cancers ascertained via linkage to western Washington Surveillance, Epidemiology, End (SEER) program. Hazard ratios (HRs) 95% confidence intervals (95% CIs) estimated using Cox proportional hazards regressions adjustment for potential confounders. RESULTS During follow-up (median = 9 years), 2,306 diagnosed. Male not statistically significantly associated overall or subtypes cancer. CONCLUSION This study did provide support hypothesis that be a marker subsequent cancer. Previous evidence indicates distinct class frontal vertex balding increased risk aggressive cancer, but all such classes captured as single exposure category by VITAL questionnaire. Prostate 75:415–423, 2015. © 2014 Wiley Periodicals, Inc.