Amber suppressors: efficiency of chain propagation and suppressor specific amino acids.

作者: S. Kaplan , A.O.W. Stretton , S. Brenner

DOI: 10.1016/S0022-2836(65)80202-9

关键词: SerineMutationAmino acidChain propagationGlutamineTyrosineBacteriophageMolecular biologyMutantBiology

摘要: Previous experiments showed that su I + inserts serine at the site of mutation in H36, an amber mutant head protein bacteriophage T4D. The amino acids inserted by II and III are now shown to be glutamine tyrosine, respectively. efficiencies chain propagation these suppressors have been measured 63%, 51% 30% for , .

参考文章(9)
Alan Garen, Suzanne Garen, Robert C. Wilhelm, Suppressor genes for nonsense mutations. I. The Su-1, Su-2 and Su-3 genes of Escherichia coli. Journal of Molecular Biology. ,vol. 14, pp. 167- 178 ,(1965) , 10.1016/S0022-2836(65)80238-8
Gursaran W. Notani, Dean L. Engelhardt, William Konigsberg, Norton D. Zinder, SUPPRESSION OF A COAT PROTEIN MUTANT OF THE BACTERIOPHAGE F2. Journal of Molecular Biology. ,vol. 12, pp. 439- ,(1965) , 10.1016/S0022-2836(65)80266-2
S. Brenner, J.R. Beckwith, Ochre mutants, a new class of suppressible nonsense mutants Journal of Molecular Biology. ,vol. 13, pp. 629- 637 ,(1965) , 10.1016/S0022-2836(65)80131-0
A.O.W. Stretton, S. Brenner, MOLECULAR CONSEQUENCES OF THE AMBER MUTATION AND ITS SUPPRESSION. Journal of Molecular Biology. ,vol. 12, pp. 456- 465 ,(1965) , 10.1016/S0022-2836(65)80268-6
S. BRENNER, A. O. W. STRETTON, S. KAPLAN, Genetic Code: The ‘Nonsense’ Triplets for Chain Termination and their Suppression Nature. ,vol. 206, pp. 994- 998 ,(1965) , 10.1038/206994A0
M. R. Capecchi, G. N. Gussin, Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor. Science. ,vol. 149, pp. 417- 422 ,(1965) , 10.1126/SCIENCE.149.3682.417
A. S. SARABHAI, A. O. W. STRETTON, S. BRENNER, A. BOLLE, Co-Linearity of the Gene with the Polypeptide Chain Nature. ,vol. 201, pp. 13- 17 ,(1964) , 10.1038/201013A0