Increased FoxM1 expression is a target for metformin in the suppression of EMT in prostate cancer
作者： YIRU WANG , BINWEI YAO , YU WANG , MINGBO ZHANG , SHUAI FU
关键词: Oncology 、 Metformin 、 Cancer 、 Cancer research 、 Prostate cancer 、 Internal medicine 、 Biology 、 Cell cycle 、 Epithelial–mesenchymal transition 、 FOXM1 、 Oncogene 、 Cell
摘要: Forkhead box M1 (FoxM1) transcription factor is related to the pathogenesis of various malignancies and recent evidence indicates that FoxM1 promotes epithelial-mesenchymal transition (EMT) in breast cancer. Metformin can inhibit progression However, whether plays a role EMT prostate cancer (PCa) metformin suppress through PCa remain unresolved issues. In this study, we investigated expression levels protein 62 39 benign hyperplasia (BPH) samples found were higher tissues (66.1%) compared with BPH (28.2%) (p<0.05). We observed was expressed cell lines suppressed proliferation FoxM1. induced cells by addition transforming growth (TGF)-β1 verified process examining EMT-related gene (E-cadherin, vimentin Slug) expression. addition, knockdown shRNA reversed markedly reduced migration. These results indicate suppresses inhibiting demonstrate suppression may be an effective therapeutic strategy for provide further anticancer effects metformin.
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