Protein targeting to endosomes and phagosomes via FYVE and PX domains.
作者： H. C. G. Birkeland , H. Stenmark
DOI: 10.1007/978-3-642-18805-3_4
关键词: Effector 、 FYVE domain 、 Phagosome 、 Endosome 、 Phagosome maturation 、 Protein targeting 、 Biology 、 Biochemistry 、 Cell biology 、 Signal transduction 、 Endocytic cycle
摘要: Phosphatidylinositol 3-phosphate (PI3P) is generated on early endosomal and phagosomal membranes by PI 3-kinases. This lipid serves important regulatory functions in phagocytosis, endocytic traffic, receptor signalling microbial killing through the recruitment activation of a number effector proteins. Almost all these effectors contain FYVE or PX domains, functional protein modules which are conserved from yeast to mammals. Structural information available regarding binding domains PI3P. The two highly different, but they have common that clusters basic residues mediate ligand interactions with phosphate groups Most proteins serve as regulators membrane trafficking, whereas others function phagosome maturation, signal transduction, other cellular activities relevance for immune system.
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