Patient-Derived Xenograft Models for Human Cancer: The Freiburg Experience
作者： Heinz-Herbert Fiebig
DOI: 10.1007/978-3-319-57424-0_3
关键词: Medicine 、 Concordance 、 Drug resistance 、 Oncology 、 Tumor xenograft 、 First line 、 Human cancer 、 Drug 、 Cancer 、 Cancer drug discovery 、 Internal medicine
摘要: This chapter reviews the almost 40-year Freiburg experience with patient-derived mouse models of cancer. More than 3,000 patient tumors all major types have been implanted in nude nice. Take rates varied tumor types, GI high and hormone-dependent low. Tumors became established after 2-3 passages high-grade having highest establishment rate. We correlated drug response donor found a very level concordance for both resistance sensitivity. However, time necessary to establish makes them more suitable determine 2nd line therapy rather first line. Among established, 240 were reproducible behavior, could be cryo-preserved recovered from liquid nitrogen storage at frequency extensively characterized regard sensitivity by genomic profiling. set has proven highly-useful cancer discovery evaluation laboratories around world resource without equal.
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sci-hub.se 参考文章(75)
R. H. Jacobson, N. D. Reed, The immune response of congenitally athymic (nude) mice to the intestinal nematode Nippostrongylus brasiliensis. Experimental Biology and Medicine. ,vol. 147, pp. 667- 670 ,(1974) , 10.3181/00379727-147-38412
H. Henss, G.W. Lohr, H.H. Fiebig, J.R. Schmid, W. Bieser, Colony assay with human tumor xenografts, murine tumors and human bone marrow. Potential for anticancer drug development European Journal of Cancer and Clinical Oncology. ,vol. 23, pp. 937- 948 ,(1987) , 10.1016/0277-5379(87)90339-7
K. Prabhakaran, E. B. Harris, W. F. Kirchheimer, Hairless mice, human leprosy and thymus-derived-lymphocytes. Cellular and Molecular Life Sciences. ,vol. 31, pp. 784- 785 ,(1975) , 10.1007/BF01938464
FRANCIS LOOR, GEORGES E. ROELANTS, High frequency of T lineage lymphocytes in nude mouse spleen Nature. ,vol. 251, pp. 229- 230 ,(1974) , 10.1038/251229A0
Manuel Hidalgo, Elizabeth Bruckheimer, N.V. Rajeshkumar, Ignacio Garrido-Laguna, Elizabeth De Oliveira, Belen Rubio-Viqueira, Steven Strawn, Michael J. Wick, James Martell, David Sidransky, A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer Molecular Cancer Therapeutics. ,vol. 10, pp. 1311- 1316 ,(2011) , 10.1158/1535-7163.MCT-11-0233
Manuel Hidalgo, Frederic Amant, Andrew V Biankin, Eva Budinská, Annette T Byrne, Carlos Caldas, Robert B Clarke, Steven de Jong, Jos Jonkers, Gunhild Mari Mælandsmo, Sergio Roman-Roman, Joan Seoane, Livio Trusolino, Alberto Villanueva, EurOPDX Consortium, None, Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer Discovery. ,vol. 4, pp. 998- 1013 ,(2014) , 10.1158/2159-8290.CD-14-0001
Francis Loor, Georges E. Roelants, IMMUNOFLUORESCENCE STUDIES OF A POSSIBLE PRETHYMIC T-CELL DIFFERENTIATION IN CONGENITALLY ATHYMIC (NUDE) MICE Annals of the New York Academy of Sciences. ,vol. 254, pp. 226- 241 ,(1975) , 10.1111/J.1749-6632.1975.TB29173.X
Hans R. Hendriks, Simon Langdon, Dietmar P. Berger, Knut Breistøl, Heinz H. Fiebig, Øystein Fodstad, Gilberto Schwartsmann, Comparative antitumour activity of vinblastine-isoleucinate and related vinca alkaloids in human tumour xenografts. European Journal of Cancer. ,vol. 28, pp. 767- 773 ,(1992) , 10.1016/0959-8049(92)90112-F
Niko Bausch, Heinz-Herbert Fiebig, Michael Hofmann, Andre Korrat, Thomas Metz, Julia Schüler, Gene signatures developed from patient tumor explants grown in nude mice to predict tumor response to 11 cytotoxic drugs. Cancer Genomics & Proteomics. ,vol. 4, pp. 197- 209 ,(2007)
Heinz-Herbert Fiebig, Dietmar P. Berger, Bernd R. Winterhalter, Jacqueline Plowman, In vitro and in vivo evaluation of US-NCI compounds in human tumor xenografts. Cancer Treatment Reviews. ,vol. 17, pp. 109- 117 ,(1990) , 10.1016/0305-7372(90)90034-D