Topographical Distribution of Morphological Changes in a Partial Model of Parkinson’s Disease—Effects of Nanoencapsulated Neurotrophic Factors Administration
作者： C. Requejo , J. A. Ruiz-Ortega , H. Bengoetxea , A. Garcia-Blanco , E. Herrán
DOI: 10.1007/S12035-015-9234-Y
关键词: Internal medicine 、 Vascular endothelial growth factor 、 Striatum 、 Doublecortin 、 Parkinson's disease 、 Neurotrophic factors 、 Substantia nigra 、 Neuroscience 、 Chemistry 、 Endocrinology 、 Neuroregeneration 、 Glial cell line-derived neurotrophic factor
摘要: Administration of various neurotrophic factors is a promising strategy against Parkinson’s disease (PD). An intrastriatal infusion 6-hydroxidopamine (6-OHDA) in rats suitable model to study PD. This work aims describe stereological parameters regarding rostro-caudal gradient, order characterize the and verify its suitability for elucidating benefits therapeutic strategies. 6-OHDA induced reduction tyrosine hidroxylase (TH) reactivity dorsolateral part striatum, being higher caudal section than rostral one. Loss TH-positive neurons axodendritic network was highly significant external third substantia nigra (e-SN) group versus saline After administration nanospheres loaded with (NTF: vascular endothelial growth factor (VEGF) + glial cell line-derived (GDNF)), parkinsonized showed more fibers those control groups; this recovery taking place chiefly sections. Neuronal density e-SN entire SN; topographical analysis that highest difference between NTF attained middle section. A high number bromodeoxyuridine (BrdU)-positive cells were found sub- periventricular areas receiving NTF, where most them co-expressed doublecortin. Measurements on achieved specific results SN. gradients underpins usefulness topological approach assessment lesion Findings confirmed neurorestorative, neurogenic, synergistic effects VEGF + GDNF administration.
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