An epidemiological and genetic study of facial clefting in France. I. Epidemiology and frequency in relatives.

作者: C Bonaiti , M L Briard , J Feingold , B Pavy , J Psaume

DOI: 10.1136/JMG.19.1.8

关键词: Incidence (epidemiology)MedicineObstetricsAllele frequencyEpidemiologyPregnancyGeneticsMaternal effectSex ratioAbortion

摘要: The frequencies of cleft lip with or without palate (CL(P)) and isolated (CP) have been estimated in France to be 0.082% 0.035%, respectively, after exclusion malformation syndromes. A genetic epidemiological study has carried out on 468 patients CL(P) 163 CP. results are given detail some specific points discussed: the apparently low incidence France, relationship between sex ratio abortion rates, maternal effects, possibility an association

参考文章(28)
Charles M. Woolf, Paternal Age Effect for Cleft Lip and Palate American Journal of Human Genetics. ,vol. 15, pp. 389- 393 ,(1963)
R J Gorlin, J Cervenka, V E Anderson, The syndrome of pits of the lower lip and cleft lip and/or palate. Genetic considerations. American Journal of Human Genetics. ,vol. 19, pp. 416- 432 ,(1967)
F C Fraser, The genetics of cleft lip and cleft palate. American Journal of Human Genetics. ,vol. 22, pp. 336- 352 ,(1970)
J D Niswander, G J Bingle, Maternal effects in human cleft lip and palate. American Journal of Human Genetics. ,vol. 29, pp. 605- 609 ,(1977)
Broadbent Tr, Woolf Cm, Woolf Rm, A genetic study of cleft lip and palate in Utah. American Journal of Human Genetics. ,vol. 15, pp. 209- 212 ,(1963)
Alice J. Chabora, Sidney L. Horowitz, Cleft lip and cleft palate: One genetic system Oral Surgery, Oral Medicine, Oral Pathology. ,vol. 38, pp. 181- 186 ,(1974) , 10.1016/0030-4220(74)90053-X
ELIZABETH J. CURTIS, Congenital Cleft Lip and Palate American Journal of Diseases of Children. ,vol. 102, pp. 853- 857 ,(1961) , 10.1001/ARCHPEDI.1961.02080010855007
J.D. Niswander, C.S. Chung, C.J. Maclean, K. Dronamraju, Sex ratio and cleft lip with or without cleft palate. The Lancet. ,vol. 300, pp. 858- 860 ,(1972) , 10.1016/S0140-6736(72)92217-9