Synthesis and photocytotoxicity of some new substituted phthalocyanines.

摘要: Some new, ring-substituted phthalocyanines have been synthesized and underwent preliminary testing for photodynamic activity using the colony forming ability of Chinese hamster cells in culture as an endpoint. Using 4-(3-N,N-diethylaminopropyl)phthalonitrile a precursor, previously unknown metal-free 2,9,16,23-tetra-(3-N,N-diethylaminopropyl)phthalocyanine was prepared converted to its zinc (II) cationic water-soluble 2,9,16,23-tetramethylammonium iodide derivatives. Other new phthalocyanine derivatives tested, include 2,9,16,23-tetra(2-hydroxymethyl-2-methylbutoxy)phthalocyaninato 2,3,9,10,16,17,23,24-octahydroxyphthalocyaninato Boron tribromide cleavage newly fully characterized 2,3,9,10,16,17,23,24-octamethoxyphthalocyanine gave unstable octahydroxyphthalocyanine, which could only be by ultraviolet-visible, NMR IR spectroscopy.