The Roles of Imprinted SLC22A18 and SLC22A18AS Gene Overexpression Caused by Promoter CpG Island Hypomethylation as Diagnostic and Prognostic Biomarkers for Non-Small Cell Lung Cancer Patients.
作者： José Francisco Noguera-Uclés , Laura Boyero , Ana Salinas , Juan Antonio Cordero Varela , Johana Cristina Benedetti
关键词: Adenocarcinoma 、 Genomic imprinting 、 DNA methylation 、 Ademetionine 、 Cancer research 、 Gene knockdown 、 CpG site 、 Medicine 、 Lung cancer 、 Gene
摘要: Genomic imprinting is a process that involves one gene copy turned-off in parent-of-origin-dependent manner. The regulation of imprinted genes broadly dependent on promoter methylation marks, which are frequently associated with both oncogenes and tumor suppressors. purpose this study was to assess the DNA patterns solute-carrier family 22 member 18 (SLC22A18) SLC22A18 antisense (SLC22A18AS) non-small cell lung cancer (NSCLC) patients their relevance disease. We found were hypomethylated adenocarcinoma squamous carcinoma patients. Due loss, SLC22A18AS be overexpressed NSCLC tissues, significantly more evident These results validated through analyses public databases reversed profile achieved vitro by treatment ademetionine. then showed high expression levels worsening disease progression. In addition, low also correlated better overall survival for knockdown inhibits proliferation vitro. All these suggest may useful as diagnostic prognostic biomarkers NSCLC, revealing novel therapeutic opportunities.
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