Photosensitivity disorders: cause, effect and management

摘要: Abnormal photosensitivity syndromes form a significant and common group of skin diseases. They include primary (idiopathic) photodermatoses such as polymorphic light eruption (PLE), chronic actinic dermatitis (CAD), prurigo, hydroa vacciniforme solar urticaria, in addition to drug- chemical-induced photo-exacerbated dermatoses. can be extremely disabling difficult diagnose. PLE, characterized by recurrent pruritic papulo-vesicular affected within hours sun exposure, is best managed restriction ultraviolet radiation (UVR) exposure the use high protection factor (SPF) sunscreens. If these measures are insufficient, prophylactic phototherapy with PUVA, broadband UVB or narrowband (TL-01) for several weeks during spring may necessary. CAD manifests chronically sun-exposed skin. Again, UVR needs restricted; cyclosporine, azathioprine PUVA also Actinic prurigo presence excoriated papules nodules on face limbs, most prominent numerous distally. again SPF sunscreens; therapy, low doses thalidomide Hydroa causes crops discrete erythematous macules, 2 3mm size, that evolve into blisters couple days exposure. Treatment this rare disease difficult; absorbent sunscreens restricted help. Solar urticaria acute erythema urticarial wealing after UVR. options non-sedating antihistamines fexofenadine cetirizine; other sunscreens, at relevant wavelength, maintenance non-responsive state natural artificial plasmapheresis. Industrial, cosmetic therapeutic agents induce exogenous photosensitivity. The clinical pattern highly varied, depending agent; treatment based removal photosensitizer along Predominantly non-photosensitive dermatoses exacerbated precipitated UVR; should reduced advocated, appropriate underlying disease.