Multiple Calvarial Lytic Lesions: A Differential Diagnosis from Early Medieval France (5th to 7th c. AD)

作者: F. Bauduer , M. Bessou , P. Guyomarc'h , C. Mercier , D. Castex

DOI: 10.1002/OA.2256

关键词: SkullSarcoidosisLangerhans cell histiocytosisDifferential diagnosisTuberculosisPaleopathologyMultiple myelomaPathologyMedical diagnosisMedicine

摘要: A skull from the early French Medieval period presenting multiple destructive lesions is investigated. The study of this presumably young female suggests a series possible diagnoses using macroscopic features, standard radiography, CT, and 3D analysis. After review paleopathological medical literature, debate focuses on several malignant disorders (cancerous metastases, myeloma), Langerhans cell histiocytosis, other benign conditions such as infection (especially tuberculosis) or sarcoidosis. Although definite diagnosis not straightforward, histiocytosis most probable diagnosis. Copyright © 2012 John Wiley & Sons, Ltd.

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