Vaccination against δ−Retroviruses: The Bovine Leukemia Virus Paradigm
作者： Gerónimo Gutiérrez , Sabrina Rodríguez , Alix de Brogniez , Nicolas Gillet , Ramarao Golime
DOI: 10.3390/V6062416
关键词: Enzootic Bovine Leukosis 、 Virology 、 Vaccination 、 Human T-lymphotropic virus 1 、 Immunology 、 Biology 、 Vaccine efficacy 、 Leukemia 、 Deltaretrovirus 、 Bovine leukemia virus 、 Tropical spastic paraparesis
摘要: Bovine leukemia virus (BLV) and human T-lymphotropic type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) leukemia/lymphoma (adult T-cell leukemia). is major pathogen cattle, causing important economic losses due to reduction production, export limitations lymphoma-associated death. In the absence satisfactory treatment for these besides prevention transmission, best option reduce prevalence vaccination. Here, we provide an overview different vaccination strategies BLV model outline key parameters required vaccine efficacy.
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